Host resistance and immunity Essay Example | Topics and Well Written Essays - 500 words - 1

Host resistance and immunity - Essay Example In case of any change in their genotypes, both bacteria are able seek food from other sources they have not been able to get their food. This allows these bacteria to keep away from the action of destructive chemicals for instance antibiotics. This can also allow them produce chemicals that shield them from attack by organisms that have the ability of destroying them (Schindler, 2006). Both M. tuberculosis and Escherichia -coli have the small second-messenger molecule called cAMP in them as well as in the macrophage. When cAMP levels are high, it interferes with host indication pathways. However, cAMP levels within Mycobacterium Tuberculosis are many at times higher as compared to Escherichia coli. The high levels of cAMP generate it’s own series of troubles, for instance, with the purpose of the key bacterial cAMP-responsive protein, the cAMP receptor protein (CRP). These proteins manage the expression of a big number of bacterial genes by attaching to cAMP. This, in so doing undergoes allosteric alterations that enable it to attach to a definite DNA motif and as a result, interact with and engage the RNA polymerase-sigma factor complex, hence activate transcription initiation. In Mycobacterium tuberculosis, this has to happen against the conditions of extremely high cAMP levels (Qureshi, et.al, 1999). Escherichia coli play a handy role in suppressing the growth of destructive bacteria species by combining appreciable amounts of vitamins. On the other hand, Mycobacterium tuberculosis evades the human immune response by attacking host cells (New York Times, 2012). Mycobacterium tuberculosis does this by creating an intracellular environment when macrophage overwhelms a M. tuberculosis cell. It then prevents the macrophage from combining with a lysosome which contains enzymes, which then crashes foreign bodies and pathogens that attack. It does this by generating some protein which the macrophage produces and